MADE SAFE primarily uses a hazard-based approach that identifies potentially problematic ingredients and encourages substitution. Our process examines ingredients and materials using our Element360 Ingredient Database to ensure there are no known behavioral toxins, carcinogens, developmental toxins, endocrine disruptors, fire retardants, heavy metals, neurotoxins, high risk pesticides, reproductive toxins, toxic solvents, or harmful VOCs used in products. We also exercise the precautionary principle for GMOs, synthetic biology, and synthetic nanoparticles. Then we layer in our 360-degree Ecosystem Approach screening, as we work with researchers and chemists to evaluate whether each and every ingredient (and all the sub-ingredients) will bioaccumulate; persist in the water, sediment, or soil; contribute to air pollution; or cause harm to aquatic life or wildlife.