Chemical Profile: Bisphenols & BPA

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Why It Matters

Bisphenols are a family of chemically similar substances that are the structural components of plastic.  [2]  There are reportedly more than fifty bisphenol structures, including BPA, BPS, BPF, BPE, and others. A large majority of research conducted on bisphenols has been dedicated to BPA, or Bisphenol A, which can be found in many plastic items with the  recycling code #7  or recycling code #3.  [9]

What Is It?

BPA, or Bisphenol A, is a structural component of plastic that is virtually everywhere. The problem with BPA in packaging is that the chemical can migrate from packaging into the food or liquid it contains. [9]  High heat or extreme cold (i.e. microwaves, dishwashers, or freezers) can cause BPA to leach faster. Given that so many products are packaged in BPA-containing plastics, exposure to the chemical is widespread, with an overwhelming majority of the population exposed. [9] 

Chemical Profile Bisphenols & BPA MADE SAFE Blog

Where It's Found

BPA is found in numerous household products including food storage, water bottles, plastic dishes and cutlery, and food packaging.  [9]  BPA is also found in epoxy resins that line the inside of beverage cans or canned food items.  [15]

The Health Concern

Research on the risks of BPA is well established. BPA is an endocrine disrupting chemical, meaning it can interfere with hormone levels and hormonal communication. Particularly, BPA impacts estrogen receptors in the body, [7][16]  and exposure to it is linked to  inflammation ,  [13]  ovarian and breast diseases,  [13]  female and male infertility, [7]  early puberty,  [18]  breast cancer, [10][11]   childhood neurological disorders , [6]  and more.  [7]  

 

The FDA banned the use of BPA-based polycarbonate resins in baby bottles and sippy cups in July 2012, long after manufacturers already discontinued its use in these products due to consumer awareness.  [14]  This was followed by a ban on the use of BPA-based epoxy resins in infant formula packaging in July 2013.  [15]  Despite what appears to be efforts to curb BPA exposures, environmental health advocates are unhappy with the FDA’s lack of urgency in regulating BPA, in light of significant action taken by European regulators.  [3]  A draft report published in 2021 by the European Food Safety Authority (EFSA) acknowledged that adverse health effects associated with BPA can occur at exposure levels 100,000 times lower than initially believed.  [3] [4]

 

BPA’s endocrine active capabilities are relevant to human, terrestrial, and aquatic toxicity. The European Union classifies BPA as toxic to aquatic life. Exposure of aquatic life to BPA can disrupt processes related to growth, survival, and reproduction. BPA is not readily biodegradable in seawater, in contrast to its low potential for accumulation in freshwater environments. However, the persistence of BPA in effluent discharges means freshwater aquatic life is consistently exposed. In fact, a meta-analysis of peer-reviewed studies investigating the effects of BPA on aquatic organisms found freshwater environments to contain higher levels of BPA on average, compared to marine environments. 

 

BPA does not pass the MADE SAFE 360° Ecosystem Approach Screening due to its classification as an endocrine disruptor, amongst numerous other adverse health effects and environmental prevalence. 

How to Avoid It

The good news is that while BPA seems to be everywhere, you can reduce your exposure with some easy changes – and those changes really matter. For example, one study showed that people who stopped eating all canned food and food packaged in plastic for just three days showed a drop of over 60% of BPA levels in their bodies.  [12] 

Look for packaging made of glass, steel, and porcelain, rather than plastic.

When plastic cannot be avoided, choose recycling codes 1, 2, 4, and 5, as these are less toxic plastics [5] 

Buy in bulk. Utilize the bulk bins at your grocery store to reduce the amount of food packaging you come in contact with.

Go virtual. When given the option, skip the paper receipt, which can be made of BPA-containing thermal paper, [8]  and have your receipt emailed to you.

Be wary of BPA-free plastics. These can often be made of other Bisphenols, like BPS. [6]  The full extent of the health impacts of other Bisphenols are not yet widely understood by scientists, but are known to leach endocrine disrupting chemicals, [1]  so it is best to avoid them. Instead, choose alternative packaging materials as much as possible.

Look for the MADE SAFE seal on baby products and water bottles. Baby bottles, teething rings, nookies, and toys are often made of BPA-containing plastics, which can leach from the productIn addition to being BPA-free, MADE SAFE certified products are made without other toxic chemicals linked to human health issues and ecosystem harm. Find MADE SAFE certified products  here .

References

[1]   Bittner, G.D., Yang, C.Z., Stoner, M.A. (2014). Estrogenic chemicals often leach from BPA-free plastic products that are replacements for BPA-containing polycarbonate products. Environmental Health. 13: 41.  https://doi.org/10.1186/1476-069X-13-41

[2]   ECHA European Chemicals Agency. Bisphenols. Accessed December 13, 2022. Retrieved from https://echa.europa.eu/hot-topics/bisphenols

[3]   E&E News(2022). FDA agrees to reassess BPA risks. Accessed December 13, 2022. Retrieved from  https://www.eenews.net/articles/fda-agrees-to-reassess-bpa-risks/

[4]   European Food Safety Authority (EFSA)(2021). Bisphenol A: EFSA draft opinion proposes lowering the tolerable daily intake. Accessed December 13, 2022. Retrieved from https://www.efsa.europa.eu/en/news/bisphenol-efsa-draft-opinion-proposes-lowering-tolerable-daily-intake

[5]   Good Housekeeping(2022). Exactly What Every Plastic Recycling Symbol Really Means. Accessed December 13, 2022. Retrieved from https://www.goodhousekeeping.com/home/g804/recycling-symbols-plastics-460321/?slide=1

[6]   Kinch, C.D., Ibhazehiebo, K., Jeong, J., Kurrasch, D.M. (2015). Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. PNAS. 112(5): 1475-1480.  https://doi.org/10.1073/pnas.1417731112

[7]   Konieczna, A., Rutkowska, A., Rachon, D. (2015). Health risk of exposure to Bisphenol A (BPA). 66 (1): 5-1. https://pubmed.ncbi.nlm.nih.gov/25813067/

[8]   Liu, J. and Martin, J.W. (2017). Prolonged Exposure to Bisphenol A from Single Dermal Contact Events. Environ Sci Technol. 51(17): 9940-9949.  https://doi.org/10.1021/acs.est.7b03093

[9]   National Institute of Environmental Health Sciences. (2021). Bisphenol A (BPA). Accessed December 12, 2022. Retrieved from https://www.niehs.nih.gov/health/topics/agents/sya-bpa/index.cfm

[10]  Olsen, C.M., Meussen-Elholm, E.T.M., Samuelsen, M., Holme, J.A., Hongslo, J.K. (2003). Effects of the Environmental Oestrogens Bisphenol A, Tetrachlorobisphenol A, Tetrabromobisphenol A, 4-Hydroxybiphenyl and 4,4′-Dihydroxybiphenyl on Oestrogen Receptor Binding, Cell Proliferation and Regulation of Oestrogen Sensitive Proteins in the Human Breast Cancer Cell Line MCF-7. Pharmacology and Toxicology. 92(4): 180-188.  https://doi.org/10.1034/j.1600-0773.2003.920408.x

[11]  Pupo, M., Pisano, A., Lappano, R., Santolla, M.F., De Francesco, E.M., Abonante, S., Rosano, C., Maggiolini, M. (2012). Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts. Environmental Health Perspectives. 120(8): 1177-1182. https://doi.org/ 10.1289/ehp.1104526

[12]  Rudel, R.A., Gray, J.M., Engel, C.L., Rawsthorne, T.W., Dodson, R.E., Ackerman, J.M., Rizzo, J., Nudelman, J.L., Brody, J.G. (2011). Food Packaging and Bisphenol A and Bis(2-Ethyhexyl) Phthalate Exposure: Findings from a Dietary Intervention. Environmental Health Perspectives. 119(7): 914-920. https://doi.org/10.1289/ehp.1003170

[13]  Singh, S. and Shoei-Lung Li, S. (2012). Bisphenol A and phthalates exhibit similar toxicogenomics and health effects. Gene. 494 (1): 85-91. https://doi.org/10.1016/j.gene.2011.11.035

[14]   The New York Times. (2012). F.D.A Makes It Official: BPA Can’t Be Used in Baby Bottles and Cups. Retrieved from https://www.nytimes.com/2012/07/18/science/fda-bans-bpa-from-baby-bottles-and-sippy-cups.html

[15]   U.S. Food and Drug Administration (FDA)(2014). Bisphenol A (BPA): Use in Food Contact Application. Accessed December 13, 2022. Retrieved from https://www.fda.gov/food/food-additives-petitions/bisphenol-bpa-use-food-contact-application

[16]   vom Saal, F.S. and Hughes, C. (2005). An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment. Environmental Health Perspectives. 113(8): 926-933. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280330/

[17]   Wu, N.C. and Seebacher, F. (2020). Effect of the plastic pollutant bisphenol A on the biology of aquatic organisms: A meta-analysis. Glob Change Biol. 26: 3821-3833.  https://doi.org/10.1111/gcb.15127

[18]   Yum, T., Lee, S., and Kim, Y. (2012). Association between precocious puberty and some endocrine disruptors in human plasma. Journal of Environmental Science and Health, Part A. 48 (8): 912-917. https://doi.org/10.1080/10934529.2013.762734

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