Product Profile: Crib Mattresses

Product Profile Crib Mattresses MADE SAFE Blog

Toxic Chemicals in Crib Mattresses

Babies typically spend more than half of their days asleep, making their sleep environments critical to their health and wellbeing. Additionally, babies inhale more air relative to body mass[1] when compared to adults, which makes their developing systems even more vulnerable to gaseous chemicals found in their bedding and environment. In light of infants’ high susceptibility to harmful chemicals, it is important that their mattress is not a source of toxic exposures.

Ingredients of Concern

Some ingredients of concern that commonly show up in crib mattresses are:


Flame Retardants – Many crib mattresses utilize polyurethane foam and/or vinyl. Since the 1970s flame retardant chemicals have often been added to these materials to compensate for their high flammability.[2] The two major classes of flame retardants are halogenated flame retardants and organophosphorus flame retardants. Halogenated flame retardants chemicals are those containing chlorine, bromine, iodine, or fluorine; this class includes flame retardants sometimes referred to as brominated or chlorinated flame retardants.[3][4][5] Organophosphorus flame retardants are those containing phosphorous bonded to carbon.[3] The specific harmful impacts may depend based upon the variety used, but in general, chemical flame retardants have been associated with many ill effects. Animal studies have found connections between flame retardants and endocrine disruption,[5][6][7] altered neurodevelopment,[7][8][9] altered sexual development,[7][5] and thyroid dysfunction.[5] Because of the genetic and biological similarities between humans and animals, these studies can be important signals for the possible effects on humans. Human studies have linked flame retardants to negative effects such as endocrine disruption,[10] lower IQ,[11][12] hyperactivity,[13] fertility issues,[14][15] and cancer.[16] When it comes to crib mattresses, the impact on children is particularly of concern, as exposure to toxic substances, such as flame retardants, during critical windows of development can have long-lasting impacts on their health.[17] Furthermore, many flame retardant chemicals are persistent in the environment[18][3][19]20] and some are known to be toxic to aquatic life.[21] Lastly, the effectiveness of flame retardants has been met with skepticism, as they are often indiscriminately added to products where they are not truly necessary and moreover, they do not reduce fires by a substantial enough amount to outweigh the risks of their widespread use.[22]


Toxic Adhesives – Adhesives are used in lieu of traditional stitching to bind mattress materials together during manufacturing. N-propyl bromide or nPB (also known as 1-bromopropane or 1-BP), a popular adhesive, has been linked to neurotoxicity[23][24] and has been categorized as reasonably anticipated to be a human carcinogen by the National Institutes of Health (NIH) due to sufficient evidence of cancer in animal studies.[25] In 2020, the EPA granted petitions to add nPB to the list of hazardous air pollutantsregulated under the Clean Air Act given its evidence of adverse health and environmental impacts, meaning its future use in the U.S. will be highly regulated and restricted.[26] Manufacturers have also been known to use other adhesive chemicals like hot melt adhesives, water-based adhesives, acetone adhesives, acrylate resins, and even formaldehyde. Due to the fact that adhesive formulations are often considered proprietary information (under trade secret laws), there is sadly little known about what exactly comprises most mattress glues, though the information that is available does not appear favorable from a toxicity standpoint.


Per- and polyfluoroalkyl substances (PFAS)PFAS are a group of thousands of substances utilized for their ability to repel liquid, and may therefore also be used in the waterproofing of crib mattresses. Unfortunately, because PFAS chemicals are commonly used to treat the materials used to make the mattresses, you will not always find their use disclosed by the manufacturer or listed as an “ingredient” on the tag. This group of chemicals has been associated with numerous detrimental effects including endocrine disruption,[27][28][29][30][31] bioaccumulation,[32][33][34] and cancer.[35][36][37] In 2023, the International Agency for research on Cancer (IARC) finalized a significant re-evaluation of two major PFAS compounds, upgrading PFOA (perfluorooctanoic acid) to Group 1 (“Carcinogenic to humans”) and PFOS (perfluorooctanesulfonic acid) to Group 2B (“Possibly carcinogenic to humans”).[38][39] While it is encouraging to see increased recognition of the harms caused by these chemicals, manufacturers have regrettably replaced PFOA and PFOS with other PFAS possessing similar properties, meaning they likely have comparable negative effects.[40]


Additionally, PFAS are water soluble and are highly persistent in the environment, making their presence in the world both ubiquitous and nearly irreversible.[40] They have been found to bioaccumulate in the environment—both terrestrially and aquatically—where they cause ecosystem harm indefinitely due to their lack of biodegradability.[41][42][43][44]


Polyvinyl Chloride (PVC) – Polyvinyl chloride, also known as vinyl or PVC, is sometimes used in crib mattresses to make them waterproof. From start to finish, it is one of the most toxic plastics for health and the environment. Vinyl chloride, the monomer used to produce PVC, has been linked to negative health effects like cancer[45][46][47][48] and reproductive and developmental harm.[48][49] The final PVC product may still contain residual vinyl chloride monomer from the manufacturing process. PVC is also associated with endocrine disruption as it is made using phthalates, which are known endocrine disruptors.[50] Finally, PVC is not biodegradable and highly resistant to decomposition under typical environmental conditions, contributing to pollution problems and environmental harm.[51]

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Tips for Choosing a Crib Mattress

  • Shop MADE SAFE or MADE WISE crib mattresses to ensure the product has been fully vetted for substances known or suspected to cause human and ecosystem harm.
  • Beware of greenwashing. Many crib mattresses are advertised using phrases such as “natural” or “safe.” While not all products marketed in this way are harmful, you should always rely more heavily on what the product is made of rather than taking marketing claims at face-value.
  • Bypass mattresses made with polyurethane foam or memory foam and instead, shop for bedding options that forgo the unnecessary chemical flame retardant treatments. Many natural materials like latex, wool, and cotton can meet national flammability standards without the use of chemical flame retardants.
  • Select mattresses that either use traditional stitching methods to manufacture their mattresses, or find a mattress certified by a trusted third-party source like MADE SAFE or MADE WISE to ensure that any adhesives utilized are safe. Our certifications require the full disclosure of all material inputs, meaning there are no secret, unreviewed substances permitted in a product.
  • Avoid mattresses that may have been treated with PFAS or other chemicals by steering clear of claims like “waterproof” or “stain resistant.” If a product is claiming that it is waterproof without disclosing how it is waterproof, that is most likely a red flag. You can always contact the company to ensure that the product has not been treated with PFAS.
  • Do not purchase mattresses containing PVC/vinyl.

References

[1] In Exposure to Emissions of Volatile Organic Compounds From Crib Mattresses. Brandon E Boor, Helena Jarnstrom, Atila Novoselac, Ying Xu. (2014, March). National Library of Medicine.  https://pubmed.ncbi.nlm.nih.gov/24548111/


[2] National Institute of Environmental Health Sciences. (2023). Flame Retardants. Accessed March 30, 2023. Retrieved from https://www.niehs.nih.gov/health/topics/agents/flame_retardants/index.cfm


[3] Green Science Policy Institute. (2013). Flame retardants. Retrieved from http://greensciencepolicy.org/topics/flame-retardants/


[4] Siddiqi, M. A., Laessig, R. H., & Reed, K. D. (2003). Polybrominated diphenyl ethers (PBDEs): New Pollutants–Old diseases. Clinical Medicine & Research, 1(4), 281-290. Retrieved from http://www.clinmedres.org/content/1/4/281.abstract


[5] Springer, C., Dere, E., Hall, S. J., McDonnell, E. V., Roberts, S. C., Butt, C. M., Boekelheide, K. (2012). Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-, a novel brominated flame retardant present in indoor dust. Environmental Health Perspectives, 120(12), 1711. Retrieved from https://doi.org/10.1289/ehp.1204932


[6] Macaulay, L. J., Chen, A., Rock, K. D., Dishaw, L. V., Dong, W., Hinton, D. E., & Stapleton, H.M. (2015). Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquatic Toxicology, 168, 38-47. https://doi.org/10.1016/j.aquatox.2015.09.007


[7] Patisaul H.B., Roberts S.C., Mabrey N., McCaffrey K.A., Gear R.B., Braun J., Belcher S.M., Stapleton H.M. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. J Biochem Mol Toxicol. 2013 Feb;27(2):124-36. doi: 10.1002/jbt.21439. Epub 2012 Nov 8. PMID: 23139171; PMCID: PMC3788594.


[8] Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Heather B Patisaul. (2018). EDC IMPACT: Molecular effects of developmental FM 550 exposure in wistar rat placenta and fetal forebrain. Endocrine Connections, 7(2), 305-324. https://doi.org/10.1530/EC-17-0373


[9] Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. Toxicology. 2017 Sep 1;390:32-42. doi: 10.1016/j.tox.2017.08.009. Epub 2017 Aug 26. PMID: 28851516; PMCID: PMC5633518.


[10] Preston, E. V., McClean, M. D., Claus Henn, B., Stapleton, H. M., Braverman, L. E., Pearce, E. N., Webster, T. F. (2017). Associations between urinary diphenyl phosphate and thyroid function. Environment International, 101, 158-164. https://doi.org/10.1016/j.envint.2017.01.020


[11] Eskenazi, B., Chevrier, J., Rauch, S. A., Kogut, K., Harley, K. G., Johnson, C., Trujillo, C., Sjödin, A., & Bradman, A. (2013). In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environmental Health Perspectives, 121(2), 257–262. https://doi.org/10.1289/ehp.1205597


[12] Herbstman JB, Sjödin A, Kurzon M, Lederman SA, Jones RS, Rauh V, Needham LL, Tang D, Niedzwiecki M, Wang RY, Perera F. Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect. 2010 May;118(5):712-9. doi: 10.1289/ehp.0901340. Epub 2010 Jan 4. PMID: 20056561; PMCID: PMC2866690.


[13] Roze, E., Meijer, L., Bakker, A., Van Braeckel, Koenraad N J A, Sauer, P. J., & Bos, A. F. (2009). Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age. Environmental Health Perspectives, 117(12), 1953-1958. https://doi.org/10.1289/ehp.0901015


[14] Carignan, C. C., Mínguez-Alarcón, L., Williams, P. L., Meeker, J. D., Stapleton, H. M., Butt, C. 35 M., Hauser, R. (2018). Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization. Environment International, 111, 232-238. https://doi.org/10.1016/j.envint.2017.12.005


[15] Meeker, J. D., Johnson, P. I., Camann, D., & Hauser, R. (2009). Polybrominated diphenyl ether (PBDE) concentrations in house dust are related to hormone levels in men. Science of the Total Environment, 407(10), 3425-3429. https://doi.org/10.1016/j.scitotenv.2009.01.030


[16] Hoffman, K., Lorenzo, A., Butt, C. M., Hammel, S. C., Henderson, B. B., Roman, S. A., Sosa, J. A. (2017). Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: A case-control study. Environment International, 107, 235-242. https://doi.org/10.1016/j.envint.2017.06.021


[17] Jones-Otazo, H. A., Clarke, J. P., Diamond, M. L., Archbold, J. A., Ferguson, G., Harner, T., Wilford, B. (2005). Is house dust the missing exposure pathway for PBDEs? an analysis of the urban fate and human exposure to PBDEs. Environmental Science & Technology, 39(14), 5121-5130. https://doi.org/10.1021/es048267b


[18] Baron, E., Gimenez, J., Verborgh, P., Gauffier, P., De Stephanis, R., Eljarrat, E., & Barcelo, D. 57 (2015). Bioaccumulation and biomagnification of classical flame retardants, related halogenated natural compounds and alternative flame retardants in three delphinids from southern European waters. Environmental Pollution, 203, 107-115. 10.1016/j.envpol.2015.03.041 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/25875161


[19] Ross, P. S. (2005). Fireproof killer whales (Orcinus orca): Flame-retardant chemicals and the conservation imperative in the charismatic icon of British Columbia, Canada. Canadian Journal of Fisheries and Aquatic Sciences, 63(1), 224-234. Retrieved from https://doi.org/10.1139/f05-244


[20] United States Environmental Protection Agency, (EPA). (2015). Flame retardants used in flexible polyurethane foam: An alternatives assessment update. Retrieved from https://www.epa.gov/sites/production/files/2015-08/documents/ffr_final.pdf


[21] Gerlach, C. V., Das, S. R., Volz, D. C., Bisson, W. H., Kolluri, S. K., & Tanguay, R. L. (2014). Mono-substituted isopropylated triaryl phosphate, a major component of firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Aquatic Toxicology, 154, 71-79. https://doi.org/10.1016/j.aquatox.2014.05.007


[22] Interlandi J. New Warning to Consumers: Avoid These Flame Retardants. Consumer Reports. September 29, 2017. Accessed February 15, 2026. https://www.consumerreports.org/toxic-chemicals-substances/avoid-these-flame-retardants-cpsc-warning/


[23] Ichihara G, Kitoh J, Li W, Ding X, Ichihara S, Takeuchi Y. Neurotoxicity of 1-bromopropane: Evidence from animal experiments and human studies. Journal of Advanced Research. 2012;3(2):91-98. doi: 10.1016/j.jare.2011.04.005


[24] Toxicological Profile for 1-Bromopropane. In: Toxicological Profile for 1-Bromopropane. Agency for Toxic Substances and Disease Registry (US); 2017. Accessed February 16, 2026. https://www.ncbi.nlm.nih.gov/books/NBK591365/


[25] NIH. 1-Bromopropane. In: 15th Report on Carcinogens [Internet]. National Toxicology Program; 2021. Accessed February 16, 2026. https://www.ncbi.nlm.nih.gov/books/NBK590752/


[26] US EPA. Addition of 1-BP (nPB) to the Clean Air Act List of Hazardous Air Pollutants. December 22, 2016. Accessed February 16, 2026. https://www.epa.gov/haps/addition-1-bp-npb-clean-air-act-list-hazardous-air-pollutants


[27] Du X, Wu Y, Tao G, et al. Association between PFAS exposure and thyroid health: A systematic review and meta-analysis for adolescents, pregnant women, adults and toxicological evidence. Science of The Total Environment. 2024;953:175958. doi: 10.1016/j.scitotenv.2024.175958


[28] White SS, Fenton SE, Hines EP. Endocrine disrupting properties of perfluorooctanoic acid,. J Steroid Biochem Mol Biol. 2011;127(1-2):16-26. doi: 10.1016/j.jsbmb.2011.03.011


[29] Berg V, Nøst TH, Hansen S, et al. Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach. Environ Int. 2015;77:63-69. doi: 10.1016/j.envint.2015.01.007


[30] Fenton SE, Ducatman A, Boobis A, et al. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. Environ Toxicol Chem. 2021;40(3):606-630. doi: 10.1002/etc.4890


[31] Maxwell DL, Petriello MC, Pilsner JR. PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics. Semin Reprod Med. 2024;42(4):288-301. doi: 10.1055/s-0044-1801363


[32] Domingo JL. A review of the occurrence and distribution of Per- and polyfluoroalkyl substances (PFAS) in human organs and fetal tissues. Environmental Research. 2025;272:121181. doi: 10.1016/j.envres.2025.121181


[33] US EPA. Our Current Understanding of the Human Health and Environmental Risks of PFAS. October 14, 2021. Accessed February 17, 2026. https://www.epa.gov/pfas/our-current-understanding-human-health-and-environmental-risks-pfas


[34] Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS). National Institute of Environmental Health Sciences. Accessed February 17, 2026. https://www.niehs.nih.gov/health/topics/agents/pfc


[35] Li S, Oliva P, Zhang L, et al. Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States. J Expo Sci Environ Epidemiol. 2025;35(3):425-436. doi: 10.1038/s41370-024-00742-2


[36] Steenland K, Winquist A. PFAS and cancer, a scoping review of the epidemiologic evidence. Environmental Research. 2021;194:110690. doi: 10.1016/j.envres.2020.110690


[37] Goodrich JA, Walker D, Lin X, et al. Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort. JHEP Rep. 2022;4(10):100550. doi: 10.1016/j.jhepr.2022.100550


[38] IARC Monographs evaluate the carcinogenicity of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). Accessed February 16, 2026. https://www.iarc.who.int/news-events/iarc-monographs-evaluate-the-carcinogenicity-of-perfluorooctanoic-acid-pfoa-and-perfluorooctanesulfonic-acid-pfos


[39] Zahm S, Bonde JP, Chiu WA, et al. Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid. The Lancet Oncology. 2024;25(1):16-17. doi: 10.1016/S1470-2045(23)00622-8


[40] A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? | Environmental Science & Technology. Accessed February 17, 2026. https://pubs.acs.org/doi/10.1021/acs.est.6b04806


[41] Khan B, Burgess RM, Cantwell MG. Occurrence and Bioaccumulation Patterns of Per- and Polyfluoroalkyl Substances (PFAS) in the Marine Environment. ACS ES T Water. 2023;3(5):1243-1259. doi: 10.1021/acsestwater.2c00296


[42] Strong bioaccumulation of a wide variety of PFAS in a contaminated terrestrial and aquatic ecosystem. Environment International. 2025;202:109629. doi: 10.1016/j.envint.2025.109629


[43] Kotalik CJ, Hubbard LE, Perrotta BG, et al. Bioaccumulation and Transfer of Per- and Polyfluoroalkyl Substances (PFAS) in a Stream and Riparian Food Web Contaminated by Food Processing Wastewater. Environ Sci Technol. 2025;59(36):19444-19456. doi: 10.1021/acs.est.5c04867


[44] Taher H, Lohmann R. Chapter 11 Bioaccumulation of legacy and novel PFAS in the environment. In: Naidu R, Mallavarapu M, Liu Y, Umeh A, eds. Per- and Polyfluorinated Alkyl Substances. De Gruyter; 2025:495-518. doi: 10.1515/9783110796797-011


[45] IARC. 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Accessed February 17, 2026. http://publications.iarc.who.int/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/1-3-Butadiene-Ethylene-Oxide-And-Vinyl-Halides-Vinyl-Fluoride-Vinyl-Chloride-And-Vinyl-Bromide--2008


[46] US EPA. Vinyl chloride CASRN 75-01-4 | DTXSID8021434 | IRIS | US EPA, ORD. Accessed February 17, 2026. https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=1001


[47] Vinyl Chloride - Cancer-Causing Substances - NCI. March 20, 2015. Accessed February 17, 2026. https://www.cancer.gov/about-cancer/causes-prevention/risk/substances/vinyl-chloride


[48] Vinyl Chloride | Toxic Substances | Toxic Substance Portal | ATSDR. Accessed February 17, 2026. https://wwwn.cdc.gov/TSP/substances/ToxSubstance.aspx?toxid=51


[49] US EPA. Risk Evaluation for Vinyl Chloride. January 14, 2025. Accessed February 17, 2026. https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/risk-evaluation-vinyl-chloride


[50] US EPA. Biomonitoring - Phthalates. May 19, 2015. Accessed February 17, 2026. https://www.epa.gov/americaschildrenenvironment/biomonitoring-phthalates


[51] Kudzin MH, Piwowarska D, Festinger N, Chruściel JJ. Risks Associated with the Presence of Polyvinyl Chloride in the Environment and Methods for Its Disposal and Utilization. Materials (Basel). 2023;17(1):173. doi: 10.3390/ma17010173

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